Development of non-β-Lactam covalent allosteric inhibitors targeting PBP2a in Methicillin-Resistant Staphylococcus aureus
Bogdan M. Benin, Rupak Kharel, Trae Hillyer, Chuanqi Sun, A. M. Cmolik, Taylor S. Kuebler, Yuk Yin Sham, Robert A. Bonomo, Jeffrey D. Mighion, Woo Shik Shin
This study develops non-β-lactam covalent allosteric inhibitors targeting PBP2a in MRSA, showing enhanced cell inhibition and antimicrobial activity against resistant strains.
bioRxiv · May 29, 2024 · PreprintMicrobiology