Robert A. Bonomo

Adaptive landscape of the metallo-β-lactamase NDM to emerging β-lactam-based therapies

This study explores how NDM-1 evolves under different therapeutic pressures to predict resistance to emerging β-lactam-based therapies.

A Mechanism Based Pharmacokinetic/Pharmacodynamic Analysis of Polymyxin B-Based Combination Therapy Against Carbapenem-Resistant Klebsiella pneumoniae Isolates with Diverse Phenotypic and Genotypic Resistance Mechanisms

This study develops a mechanism-based pharmacokinetic/pharmacodynamic model to evaluate PMB-based combination therapy against CRKP, showing synergistic effects with lower PMB doses.

Emerging Resistance to Novel -βLactam β-Lactamase Inhibitor Combinations in Klebsiella pneumoniae bearing KPC Variants

This study identifies emerging resistance in KPC variants of K. pneumoniae to CZA, FDC, and FPZ, with mutations in specific regions linked to collateral resistance.

Dynamic Differences in Clinically relevant Pen β-Lactamases from Burkholderia spp.

This study uses computational methods to analyze dynamic differences among Pen β-lactamases from Burkholderia spp., identifying critical mutations and functional hotspots.

Mechanistic Basis for Inhibition of the Extended Spectrum Class A b-Lactamase GES-1 by Tazobactam and Enmetazobactam

This paper investigates how enmetazobactam and tazobactam inhibit GES-1, an ESBL, revealing structural and mechanistic differences in their acyl-enzyme complexes.

OXA beta-lactamases from Acinetobacter spp. are membrane-bound and secreted into outer membrane vesicles

This paper identifies membrane-bound OXA beta-lactamases in Acinetobacter spp. and shows they are secreted into outer membrane vesicles, contributing to antimicrobial resistance.

Functionally Important Residues from Graph Analysis of Coevolved Dynamic couplings

This paper introduces DyNoPy, a method combining coevolution analysis and molecular dynamics to predict functionally important residues in proteins, demonstrating its application on beta-lactamases.

Development of non-β-Lactam covalent allosteric inhibitors targeting PBP2a in Methicillin-Resistant Staphylococcus aureus

This study develops non-β-lactam covalent allosteric inhibitors targeting PBP2a in MRSA, showing enhanced cell inhibition and antimicrobial activity against resistant strains.

Specific protein-membrane interactions promote the export of metallo-β-lactamases via outer membrane vesicles

The paper shows that specific protein-membrane interactions enhance the export of metallo-β-lactamases into outer membrane vesicles in Gram-negative bacteria.