Pancreatic Beta Cell Autophagy is Impaired in Type 1 Diabetes
C. Muralidharan, A. M. Conteh, M. R. Marasco, J. J. Crowder, J. Kuipers, P. de Boer, B. N. G. Giepmans, A. K. Linnemann
This study shows impaired autophagy in pancreatic beta cells of type 1 diabetes patients and a mouse model, with reduced autophagosome-lysosome colocalization and telolysosome accumulation.
bioRxiv · Sep 10, 2020Cell Biology