Author

C. Muralidharan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 4

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Research Focus:cell type annotation· 4 Organism:human· 4 Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Assay:proteomics· 2

Frequent Co-Authors

A. K. Linnemann· 2 shared J. J. Crowder· 2 shared A. Chakraborty· 1 shared A. M. Conteh· 1 shared A. N. Novak· 1 shared B. Duffett· 1 shared B. N. G. Giepmans· 1 shared B.-J. M. Webb-Robertson· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

A. K. Linnemann

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4 papers

Recent·Most cited

Inhibition of the Eukaryotic Initiation Factor-2-α Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice

C. Muralidharan, F. Huang, J. R. Enriquez, J. E. Wang, J. B. Nelson, T. Nargis, S. C. May, A. Chakraborty, K. T. Figatner, S. Navitskaya, C. M. Anderson, V. Calvo, D. Surguladze, M. J. Mulvihill, X. Yi, , R. G. Mirmira

This study shows that inhibiting PERK reduces autoimmune diabetes risk in mice by decreasing β cell immunogenicity and improving islet function.

bioRxiv · Oct 6, 2023Cell Biology

Real Time In vivo Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune Diabetes

O. Melnyk, C. Muralidharan, B. Duffett, A. N. Novak, G. Perez-Aviles, M. M. Martinez, J. J. Crowder, A. K. Linnemann

This study uses intravital microscopy to show autophagic flux defects in NOD mouse beta-cells before hyperglycemia onset, suggesting a causal role in T1D pathogenesis.

bioRxiv · May 23, 2023 · PreprintCell Biology

Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet

R. N. Bone, X. Tong, S. A. Weaver, C. Muralidharan, P. Krishnan, T. M. Kono, C. Evans-Molina

This study shows that loss of SPCA1 in pancreatic beta cells reduces Golgi Ca2+ levels, impairs glucose-stimulated insulin secretion, and decreases autophagy.

bioRxiv · Aug 30, 2021 · PreprintCell Biology

Pancreatic Beta Cell Autophagy is Impaired in Type 1 Diabetes

C. Muralidharan, A. M. Conteh, M. R. Marasco, J. J. Crowder, J. Kuipers, P. de Boer, B. N. G. Giepmans, A. K. Linnemann

This study shows impaired autophagy in pancreatic beta cells of type 1 diabetes patients and a mouse model, with reduced autophagosome-lysosome colocalization and telolysosome accumulation.

bioRxiv · Sep 10, 2020Cell Biology