CD8 T cell hyperfunction and reduced tumour control in models of advanced liver fibrosis
J. Madani, J. Li, A. Vranjkovic, K. Jorritsma, M. S. Hasim, M. Daneshmand, A. C. Cheung, A. M. E. Ching, J. E. Bruin, M. Ardolino, A. M. Crawley
This study shows that chronic liver fibrosis leads to systemic CD8+ T cell hyperfunction, impairing tumor control and immune response.
bioRxiv · Sep 20, 2023 · PreprintImmunology