Author

A. M. Crawley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Vranjkovic· 2 shared C. L. Cooper· 2 shared J. Li· 2 shared M.-A. Langlois· 2 shared A. C. Cheung· 1 shared A. M. E. Ching· 1 shared C. A. Piccirillo· 1 shared C. Arnold· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

A. Vranjkovic

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multi-variate statistical and machine learning reveals the interplay between sex and age in antibody responses to de novo SARS-CoV-2 infection and vaccination

M. Cuperlovic-Culf, S. Bennett, Y. Galipeau, P. S. McCluskie, C. Arnold, S. Bagheri, C. L. Cooper, M.-A. Langlois, J. Fritz, C. A. Piccirillo, A. M. Crawley

The paper uses statistical and machine learning methods to analyze how sex and age influence antibody responses to SARS-CoV-2 infection and vaccination.

bioRxiv · Dec 5, 2023Immunology

Differential and lasting gene expression changes in circulating CD8 T cells in chronic HCV infection with cirrhosis and related insights on the role of Hedgehog signaling

J. Li, A. Vranjkovic, D. Read, S. P. Delaney, W. L. Stanford, C. L. Cooper, A. M. Crawley

This study examines gene expression changes in CD8 T cells from HCV-infected individuals with varying fibrosis stages, identifying lasting hyperfunction and upregulated Hedgehog signaling in cirrhosis.

bioRxiv · Sep 20, 2023Immunology

CD8 T cell hyperfunction and reduced tumour control in models of advanced liver fibrosis

J. Madani, J. Li, A. Vranjkovic, K. Jorritsma, M. S. Hasim, M. Daneshmand, A. C. Cheung, A. M. E. Ching, J. E. Bruin, M. Ardolino, A. M. Crawley

This study shows that chronic liver fibrosis leads to systemic CD8+ T cell hyperfunction, impairing tumor control and immune response.

bioRxiv · Sep 20, 2023 · PreprintImmunology

In vitro hepatitis C virus infection and hepatic choline metabolism

K. Gobeil Odai, C. O'Dwyer, R. Steenbergen, T. A. Shaw, T. M. Renner, P. Ghorbani, M. Rezaaifar, S. Han, M.-A. Langlois, A. M. Crawley, R. S. Russell, J. P. Pezacki, D. L. Tyrrell, M. D. Fullerton

This study investigates how hepatitis C virus (HCV) infection affects choline metabolism in liver cells, showing that choline transport and metabolism are modulated during early infection, with varying effects depending on culture conditions.

Viruses · Jan 16, 2020Peer-reviewedCell Biology