Dual activity of PNGM-1, a metallo-β-lactamase and tRNase Z, pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases
J. H. Lee, M. Takahashi, J. H. Jeon, L.-W. Kang, M. Seki, K. S. Park, M.-K. Hong, Y. S. Park, T. Y. Kim, A. M. Karim, J.-H. Lee, M. Nashimoto, S. H. Lee
This paper identifies PNGM-1, a dual-activity enzyme with metallo-β-lactamase and tRNase Z functions, and shows it evolved from tRNase Z, providing insights into the origin of subclass B3 metallo-β-lactamases.
bioRxiv · Mar 13, 2019Microbiology