M. Seki

Decrease in Purifying Selection Pressures on Wheat Homoeologous Genes: Tetraploidization vs Hexaploidization

The paper compares the impact of tetraploidization and hexaploidization on selection pressures of homoeologous genes in wheat, finding tetraploidization has a greater effect.

Phosphodiesterase-5 inhibition inhibits epithelial ATP release and restores detrusor contractility in rats with type 2 diabetes via an increase in bladder blood flow

This study shows that PDE-5 inhibition improves bladder function in T2DM rats by increasing blood flow, reducing ATP release, and modulating inflammatory and growth factor markers.

Synaptic plasticity in the medial preoptic area of male mice encodes social experiences with female and regulates behavior toward young

This study identifies synaptic plasticity in the medial preoptic area of male mice as critical for shifting from aggressive to paternal behavior after mating and interaction with pups.

Evolution of self-sustained circadian rhythms requires seasonal change of daylight

This study shows that seasonality promotes the evolution of self-sustained circadian rhythms through computational modeling of gene regulatory networks under light cycles.

Virological characteristics of SARS-CoV-2 BA.2 variant

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

Single mutation makes Escherichia coli an insect mutualist

The paper shows that a single mutation in E. coli enables it to become an insect mutualist by disrupting carbon catabolite repression.

A high resolution single molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis

This paper introduces a new Arabidopsis transcriptome dataset with improved accuracy and resolution using novel Iso-seq analysis methods, enhancing transcript expression and splicing analysis.

Genes for tRNA recycling are upregulated in response to infection with Theiler's mouse encephalitis virus

The paper investigates how viral infection affects tRNA recycling by analyzing mRNA levels of tRNase ZS and TRNT1 in HeLa cells, finding upregulation in response to Theiler's mouse encephalitis virus but not influenza A virus.

Genome-wide analysis of long noncoding RNAs, 24-nt siRNAs, DNA methylation and H3K27me3 marks in Brassica rapa and related species

This study analyzes lncRNAs, 24-nt siRNAs, DNA methylation, and H3K27me3 in Brassica rapa and related species to understand their epigenetic interactions and conservation patterns.

The histidine phosphotransfer AHP4 plays a negative role in Arabidopsis plant response to drought

This study shows AHP4 negatively regulates Arabidopsis drought response by modulating gene expression related to stress tolerance mechanisms.

MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

This study shows that MCM10 compensates for c-Myc-induced DNA replication stress in breast cancer stem-like cells, promoting genome duplication and drug resistance.

Removal of repressive histone marks creates epigenetic memory of recurring heat in Arabidopsis

The paper shows that JMJ proteins remove repressive histone marks in Arabidopsis, enabling epigenetic memory of heat exposure to improve heat tolerance.

A single CRISPR base editor to induce simultaneous C-to-T and A-to-G mutations

This paper introduces Target-ACE, a CRISPR base editor that induces both C-to-T and A-to-G mutations, showing higher efficiency than using separate editors.

Dual activity of PNGM-1, a metallo-β-lactamase and tRNase Z, pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases

This paper identifies PNGM-1, a dual-activity enzyme with metallo-β-lactamase and tRNase Z functions, and shows it evolved from tRNase Z, providing insights into the origin of subclass B3 metallo-β-lactamases.

A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

This study identifies ANAC044 and ANAC085 as key regulators of DNA damage-induced G2 arrest in Arabidopsis, showing their role in enhancing Rep-MYB accumulation and cell cycle arrest under specific stress conditions.

Repeated inversions at the pannier intron drive diversification of intraspecific colour patterns of ladybird beetles

The paper identifies pannier as a key regulatory gene for color pattern variation in ladybird beetles and shows that inversions and cis-regulatory changes at this gene drive intraspecific diversity.