M. Takahashi

Comparative genome analysis of Corynebacterium ulcerans Japanese isolates revealed domestically and globally diverse geographical distribution of the organism of different types.

The paper analyzes over 700 genomes of Corynebacterium ulcerans and C. ramonii isolates to reveal geographic differences in sequence types and toxigenic prophage compositions, with ST337 predominating in Japan and associations between prophage types and toxin production.

Kaempferol exerts anti-inflammatory effects by accelerating Treg development via AhR-mediated and PU.1/IRF4-dependent transactivation of the Aldh1a2/RALDH2 gene in dendritic cells

This study identifies kaempferol as a flavonoid that enhances Treg development via AhR-mediated and PU.1/IRF4-dependent activation of Aldh1a2/RALDH2 in dendritic cells, reducing inflammation in a food allergy model.

NR4A3 deficiency ameliorates contact hypersensitivity and exacerbates psoriasis by regulating gene expression in dendritic cells

This study shows NR4A3 deficiency reduces contact hypersensitivity but worsens psoriasis by altering dendritic cell gene expression.

Pigmentation level of human iPSC-derived retinal pigment epithelium cell does not indicate a specific gene expression profile

The paper analyzes the relationship between pigmentation level and gene expression in human iPSC-derived RPE cells, finding no specific gene expression profile correlates with color intensity.

Phylogenomics supports island contribution to metapopulation dynamics in a predominantly continental bird species

The paper investigates gene flow between island and continental populations of Swinhoe's Rail, finding asymmetric gene flow from island to continental populations and a role for islands as genetic reservoirs.

Low albumin status accompanies multi-layered immunosuppressive phenotypes in metastatic breast cancer patients

The paper investigates the association between low albumin levels and immunosuppressive phenotypes in metastatic breast cancer patients using transcriptomic and metabolomic data.

The genomics and evolution of inter-sexual mimicry and female-limited polymorphisms in damselflies

This study identifies the genomic basis of female-limited morphs and male mimicry in damselflies, revealing structural variants and transposable element activity driving these phenotypes.

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

This study introduces a novel fate-mapping mouse to track lymphocyte clones and their progenies in response to antigen signals, revealing distinct T cell behaviors in tumor immunity.

Kaempferol suppresses the activation of mast cells by modulating the expression of FcϵRI and SHIP1

This study shows kaempferol suppresses mast cell activation by reducing FcεRI surface expression and increasing SHIP1 levels, independent of transcription and translation.

Cotranscriptional demethylation induces global loss of H3K4me2 from active genes in Arabidopsis

This study shows that LDL3-mediated H3K4me2 demethylation occurs cotranscriptionally in Arabidopsis, disrupting the negative correlation between H3K4me2 and transcription in the ldl3 mutant.

PNPO-PLP Axis Senses Prolonged Hypoxia by Regulating Lysosomal Activity

The paper identifies the PNPO-PLP axis as a mechanism for sensing prolonged hypoxia by regulating lysosomal activity in macrophages, leading to altered inflammatory responses.

Nicotinamide-N-methyltransferase is essential for SAM and 1-methylnicotinamide homeostasis in the AML12 hepatocyte cell line

This study investigates the role of NNMT in regulating SAM and MNAM metabolism in AML12 hepatocytes, finding that NNMT is a significant consumer of SAM and critical for MNAM production.

Cryo-sensitive aggregation triggers NLRP3 inflammasome assemblyin cryopyrin-associated periodic syndrome

This study identifies cryo-sensitive NLRP3 aggregates as a scaffold for inflammasome activation in CAPS, showing Ca2+ influx is essential for this process.

Influenza A virus agnostic receptor tropism revealed using a novel biological system with terminal sialic acid-knockout cells

This paper introduces a novel system using sialic acid receptor-knockout cells to study influenza A virus receptor tropism, revealing unique biological tropism undetectable by conventional assays.

Apoplastic CBM1-interacting proteins bind conserved carbohydrate binding module 1 motifs in fungal hydrolases to counter pathogen invasion

The paper identifies OsCBMIP, a rice protein that binds to fungal CBM1 domains in xylanases, inhibiting their activity and enhancing rice defense against M. oryzae.

Genes for tRNA recycling are upregulated in response to infection with Theiler's mouse encephalitis virus

The paper investigates how viral infection affects tRNA recycling by analyzing mRNA levels of tRNase ZS and TRNT1 in HeLa cells, finding upregulation in response to Theiler's mouse encephalitis virus but not influenza A virus.

A small-molecule fluorescent probe for live-cell imaging of endocytosis

This paper introduces a fluorescent probe, ECGreen, for live-cell imaging of endocytosis, showing increased fluorescence upon internalization into acidic vesicles.

Conversion of cancer-associated fibroblasts from pro- to antitumor improves the sensitivity of pancreatic cancer to chemotherapeutics

This study converts pro-tumor CAFs to anti-tumor CAFs using Meflin induction, enhancing PDAC chemosensitivity through improved drug delivery and reduced tissue stiffness.

Purification of immunostimulatory glucose homopolymer from broccoli (Brassica oleracea var. italica)

The paper isolates and characterizes a glucose homopolymer from broccoli with immunostimulatory effects in both arthropod and mammalian systems.

Amphipathic Fluorescent Dyes for Sensitive and Long-Term Monitoring of Plasma Membranes

This paper introduces new fluorescent dyes for long-term and low-toxicity imaging of plasma membranes in neurons and exosomes.

Epithelial HVEM promotes basement membrane synthesis and intraepithelial T cell survival and migration

This study shows that epithelial HVEM supports basement membrane synthesis and IET survival and migration in the intestine.

Efficient Development of Platform Cell Lines Using CRISPR-Cas9 and Transcriptomics Analysis

The paper develops CRISPR-Cas9 mutants of U87MG cells to create platform cell lines for drug testing, finding that transcriptomic analysis helps identify clones with minimal phenotypic divergence from wild type.

Inducing Human Retinal Pigment Epithelium-like Cells from Somatic Tissue

This study develops a simplified method to induce RPE-like cells from human fibroblasts and validates their properties using single-cell RNA sequencing.

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

The paper identifies structural destabilization and degradation of MLH1 variants in Lynch syndrome, linking reduced cellular levels to loss-of-function and suggesting stability predictions for diagnostic use.

Attenuated Salmonella typhimurium cancer therapy has direct effects on the tumor epithelium in colorectal cancer

Attenuated Salmonella typhimurium reduces tumor burden in mice by directly affecting the tumor epithelium through transcriptional and metabolic changes.

Phosphoprotein-based Biomarkers as Predictors for Cancer Therapy

The paper identifies phosphoprotein biomarkers for Cdk5 activity in neuroendocrine tumors and shows their predictive value for anti-Cdk5 therapy.

Dual activity of PNGM-1, a metallo-β-lactamase and tRNase Z, pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases

This paper identifies PNGM-1, a dual-activity enzyme with metallo-β-lactamase and tRNase Z functions, and shows it evolved from tRNase Z, providing insights into the origin of subclass B3 metallo-β-lactamases.

Can Human Embryonic Stem Cell-Derived Stromal Cells Serve A Starting Material For Myoblasts?

This study generates ESC-derived CD105+ stromal cells with long-term proliferation and myogenic potential as a cell source for myoblast therapy in muscular disorders.