T. Y. Kim

Inhibition of Tgfβ signaling enables durable ventricular pacing by TBX18 gene transfer

This study shows that combining TBX18 gene transfer with Tgfβ inhibition sustains biological cardiac pacing in rats beyond four weeks.

Myofibroblast Senescence Promotes Arrhythmogenic Remodeling in the Aged Infarcted Rabbit Heart

This study shows that myofibroblast senescence in aged infarcted rabbit hearts promotes arrhythmogenic remodeling by coupling with myocytes and prolonging action potential duration.

Platycodin D prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection in vitro by hindering membrane fusion

This study shows that platycodin D inhibits SARS-CoV-2 infection by blocking lysosome- and TMPRSS2-driven entry through membrane cholesterol redistribution.

Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2

The paper computationally designs and improves a protein binder targeting HER2 domain IV, achieving a two-orders-of-magnitude increase in binding affinity through iterative computational and experimental feedback.

Dual activity of PNGM-1, a metallo-β-lactamase and tRNase Z, pinpoints the evolutionary origin of subclass B3 metallo-β-lactamases

This paper identifies PNGM-1, a dual-activity enzyme with metallo-β-lactamase and tRNase Z functions, and shows it evolved from tRNase Z, providing insights into the origin of subclass B3 metallo-β-lactamases.