MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins
T. Seo, A. M. Lowery, H. Xu, W. Giang, S. M. Troyanovsky, P. A. Vincent, A. P. Kowalczyk
This study identifies MARCH family ubiquitin ligases as regulators of cadherin degradation, showing differential targeting of VE-cadherin versus N-cadherin through specific domains and lysine residues.
bioRxiv · Aug 10, 2023Cell Biology