Author

P. A. Vincent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

A. P. Adam· 2 shared N. Martino· 2 shared S. Lu· 2 shared A. Jaitovich· 1 shared A. M. Lowery· 1 shared A. P. Kowalczyk· 1 shared D. S. Chuy· 1 shared G. Fredman· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

A. P. Adam

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Author profile →

3 papers

Recent·Most cited

MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins

T. Seo, A. M. Lowery, H. Xu, W. Giang, S. M. Troyanovsky, P. A. Vincent, A. P. Kowalczyk

This study identifies MARCH family ubiquitin ligases as regulators of cadherin degradation, showing differential targeting of VE-cadherin versus N-cadherin through specific domains and lysine residues.

bioRxiv · Aug 10, 2023Cell Biology

Shock drives a highly coordinated transcriptional and DNA methylation response in the endothelium

R. B. Ramos, N. Martino, D. S. Chuy, S. Lu, U. Balasubramanian, I. Di John Portela, P. A. Vincent, A. P. Adam

The paper investigates how shock-induced IL-6 signaling alters DNA methylation and transcription in endothelial cells, revealing a mechanism for sustained vascular dysfunction post-shock.

bioRxiv · Aug 1, 2022 · PreprintCell Biology

Endothelial SOCS3 maintains homeostasis and promotes survival in endotoxemic mice

N. Martino, R. Bossardi Ramos, S. Lu, K. Leyden, L. Tomaszek, S. Sadhu, G. Fredman, A. Jaitovich, P. A. Vincent, A. P. Adam

This paper shows that endothelial SOCS3 prevents shock-induced organ failure by inhibiting IL-6 signaling and maintaining vascular barrier function.

bioRxiv · Dec 28, 2020Cell Biology