Author

A. P. Kowalczyk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:electronic health records· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

W. Giang· 3 shared S. N. Stahley· 2 shared T. Seo· 2 shared A. Ishida-Yamamoto· 1 shared A. Kubo· 1 shared A. L. Caldara· 1 shared A. L. Mattheyses· 1 shared A. M. Lowery· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

W. Giang

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Author profile →

4 papers

Recent·Most cited

MARCH family E3 ubiquitin ligases selectively target and degrade cadherin family proteins

T. Seo, A. M. Lowery, H. Xu, W. Giang, S. M. Troyanovsky, P. A. Vincent, A. P. Kowalczyk

This study identifies MARCH family ubiquitin ligases as regulators of cadherin degradation, showing differential targeting of VE-cadherin versus N-cadherin through specific domains and lysine residues.

bioRxiv · Aug 10, 2023Cell Biology

Architecture and dynamics of a novel desmosome-endoplasmic reticulum organelle

N. K. Bharathan, W. Giang, J. S. Aaron, S. Khuon, T.-L. Chew, S. Preibisch, E. T. Trautman, L. Heinrich, J. Bogovic, D. Bennett, D. Ackerman, W. Park, A. Petruncio, A. V. Weigel, S. Saalfeld, , A. P. Kowalczyk

The paper identifies a novel subcellular architecture where the endoplasmic reticulum interacts with desmosomes and keratin filaments, influencing ER organization and dynamics.

bioRxiv · Jul 7, 2022 · PreprintCell Biology

VE-cadherin endocytosis controls vascular integrity and patterning during development

C. G. Myers, R. H. Isaacson, C. M. Cadwell, J. Campos, M. S. Hernandes, K. R. Myers, T. Seo, W. Giang, K. K. Griendling, A. P. Kowalczyk

This study shows that VE-cadherin endocytosis is essential for vascular development by promoting actin-dependent cell migration and vessel stabilization through p120 binding.

bioRxiv · Sep 13, 2019Cell Biology

The Desmosome is a Mesoscale Lipid Raft-Like Membrane Domain

J. D. Lewis, A. L. Caldara, S. E. Zimmer, A. Seybold, N. L. Strong, S. N. Stahley, A. S. Frangakis, I. Levental, J. K. Wahl, A. L. Mattheyses, T. Sasaki, K. Nakabayashi, K. Hata, Y. Matsubara, A. Ishida-Yamamoto, , A. P. Kowalczyk

The paper identifies a mutation in the desmoglein TMD that disrupts lipid raft association and desmosome formation, revealing a mesoscale lipid raft-like domain in desmosomes.

bioRxiv · Oct 15, 2018Cell Biology