Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics
B. George, A. M. Paul, P. P. Mukundan, R. Amjesh, K. Leitzel, S. M. Ali, O. Sandiford, A. Lipton, P. Rameshwar, G. N. Hortobagyi, R. M. Pillai, R. Kumar
The paper examines fitness dependencies of cancer drug targets across 19 cancer types, finding that some targets are not fitness genes and suggesting drug repurposing opportunities.
bioRxiv · Jan 28, 2021 · PreprintCancer Biology