Author

B. George

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

H. Raheja· 2 shared S. Das· 2 shared A. Abraham· 1 shared A. Assaiya· 1 shared A. B. Castillo· 1 shared A. C. Le· 1 shared A. Chen· 1 shared A. Chhabra· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersMicrobiology

H. Raheja

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Targeting Metabolic Dependencies in Acute Myeloid Leukemia: A Dual Strategy using Arsenic Trioxide and Artesunate.

N. Balasundaram, A. Venkatraman, Y. Augustin, H. K. Palani, C. Regnault, A. Korula, U. P. Kulkarni, E. S. Edison, P. Balasubramanian, B. George, A. Abraham, S. Krishna, V. Mathews

This study investigates the combination of artesunate and arsenic trioxide to treat AML with reduced off-target effects on normal hematopoietic stem cells.

bioRxiv · Jun 23, 2024 · PreprintCancer Biology

HuR enhances SARS-CoV-2 non-structural protein translation through the genomic 5'-UTR, by promoting polypyrimidine tract-binding protein binding

H. Raheja, R. Sahu, T. Ghosh, P. Rani, B. George, O. Khatun, S. Tripathi, S. Das

This paper identifies HuR's role in enhancing SARS-CoV-2 non-structural protein translation via the 5'-UTR by promoting PTB binding, while suppressing structural protein translation, and shows potential therapeutic targeting of HuR.

bioRxiv · Mar 15, 2023Microbiology

Hepatitis C virus non-structural proteins modulate cellular kinases for increased cytoplasmic abundance of host factor HuR and facilitate viral replication

H. Raheja, B. George, S. K. Tripathi, S. Saha, T. K. Maiti, S. Das

This study identifies how HCV proteins NS3 and NS5A modulate host kinases to increase cytoplasmic HuR levels, enhancing viral replication.

bioRxiv · Aug 8, 2022Microbiology

Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics

B. George, A. M. Paul, P. P. Mukundan, R. Amjesh, K. Leitzel, S. M. Ali, O. Sandiford, A. Lipton, P. Rameshwar, G. N. Hortobagyi, R. M. Pillai, R. Kumar

The paper examines fitness dependencies of cancer drug targets across 19 cancer types, finding that some targets are not fitness genes and suggesting drug repurposing opportunities.

bioRxiv · Jan 28, 2021 · PreprintCancer Biology

CASSPER: A Semantic Segmentation based Particle Picking Algorithm for Single Particle Cryo-Electron Microscopy

B. George, A. Assaiya, R. J. Roy, A. Kembhavi, R. D. Chauhan, G. Paul, J. Kumar, N. S. Philip

CASSPER automates protein particle detection in cryo-EM images using semantic segmentation, eliminating manual picking and improving detection in variable ice conditions.

bioRxiv · Jan 20, 2020Biophysics

Neogenin-1 distinguishes between myeloid-biased and balanced Hoxb5+ mouse long-term hematopoietic stem cells

G. S. Gulati, M. Zukowska, J. Noh, A. Zhang, R. Sinha, B. George, D. Wesche, I. L. Weissman, K. Szade

This paper identifies Neogenin-1 as a marker distinguishing myeloid-biased from balanced Hoxb5+ long-term hematopoietic stem cells in mice, revealing their functional heterogeneity and hierarchical relationship.

bioRxiv · Jun 26, 2019Cell Biology

Enabling MHC-mismatched hematopoietic stem cell transplants and organ graft tolerance without chemotherapy or radiation

B. George, K. S. Kao, A. Chen, A. C. Le, A. Chhabra, C. Burnett, K. M. Loh, J. A. Shizuru, I. Weissman

This study develops six monoclonal antibodies to deplete immune cells in mice, enabling MHC-mismatched HSC transplants without chemotherapy or radiation, leading to immune tolerance.

bioRxiv · Jan 21, 2019 · PreprintImmunology

Effects of mechanical loading on cortical defect repair using a novel mechanobiological model of bone healing

C. Liu, R. Carrera, V. Flamini, L. Kenny, P. Cabahug-Zuckerman, B. George, D. Hunter, B. Liu, G. Singh, P. Leucht, K. A. Mann, J. A. Helms, A. B. Castillo

This study shows that mechanical loading at different stages of cortical bone healing affects repair outcomes, with loading during matrix deposition enhancing bone and cartilage formation.

bioRxiv · Sep 19, 2017Bioengineering