Extracellular heparan 6-O-endosulfatases SULF1 and SULF2 in HNSC and other malignancies
Y. Yang, J. Ahn, N. J. Edwards, J. Benicky, A. M. Rozeboom, B. Davidson, C. Karamboulas, K. Nixon, L. Ailles, R. Goldman
The paper investigates SULF1 and SULF2 in HNSC and other cancers, finding SULF1 is secreted by fibroblasts and negatively impacts survival early, while SULF2, from tumor cells, affects survival later, with implications for therapy.
bioRxiv · Aug 25, 2022 · PreprintCancer Biology