R. Goldman

Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2

This study identifies LG3BP as a binding partner of Sulf-2 in HNSCC and shows that LG3BP inhibits Sulf-2 activity, reducing HNSCC cell invasion.

Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts

This study shows that Sulf-2 promotes HNSCC cell invasion in co-cultures with CAFs, and a marine glycosaminoglycan inhibits this effect.

Ghost fragment ions in structure and site-specific glycoproteomics analysis

The paper identifies 'Ghost' fragment ions in glycoproteomics that can lead to false positive structure assignments and proposes a minimal intensity threshold to mitigate this issue.

Extracellular heparan 6-O-endosulfatases SULF1 and SULF2 in HNSC and other malignancies

The paper investigates SULF1 and SULF2 in HNSC and other cancers, finding SULF1 is secreted by fibroblasts and negatively impacts survival early, while SULF2, from tumor cells, affects survival later, with implications for therapy.

LC-MS/MS-PRM Quantification of IgG glycoforms using stable isotope labeled IgG1 Fc glycopeptide standard

The paper introduces a workflow for quantifying IgG glycoforms using stable isotope labeled standards and LC-MS/MS-PRM, achieving high sensitivity and precision.

Vimentin Intermediate Filaments and Filamentous Actin Form Unexpected Interpenetrating Networks That Redefine the Cell Cortex

This study reveals that vimentin intermediate filaments and F-actin form an interpenetrating network in the cell cortex, enhancing contractile forces and influencing actin dynamics.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

Immunogenicity of novel mRNA COVID-19 vaccine MRT5500 in mice and non-human primates

This study evaluates the immunogenicity of the mRNA vaccine MRT5500 in mice and non-human primates, showing it elicits neutralizing antibodies and TH1-biased responses.

Analysis of site and structure specific core fucosylation in liver disease progression using exoglycosidase-assisted data-independent LC-MS/MS

This study quantifies core fucosylation changes in liver disease using mass spectrometry and exoglycosidase-assisted analysis of glycopeptides.

N and O glycosylation of the SARS-CoV-2 spike protein

This study identifies O- and N-glycosylation sites on the SARS-CoV-2 spike protein and their structural motifs, revealing their potential role in proteolytic activation.

PD-L1 glycosylation and its impact on binding to clinical antibodies

This study investigates PD-L1 glycosylation patterns and their impact on interactions with PD-1 and clinical antibodies, revealing site-specific glycan structures and potential functional implications.

Acto-myosin network geometry defines centrosome position

This study shows that centrosome positioning is determined by actin network geometry rather than cell shape, with dynein forces placing the centrosome in an inner zone defined by actin contraction.

Vimentin protects the structural integrity of the nucleus and suppresses nuclear damage caused by large deformations

This study shows that vimentin intermediate filaments protect the nucleus from damage during cell migration by maintaining its shape and mechanical integrity.

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

The paper shows that chromatin histone modifications affect nuclear rigidity and morphology independently of lamins, inducing or suppressing nuclear blebs through changes in chromatin compaction.