Poly-glutamine-dependent self-association as a potential mechanism for regulation of androgen receptor activity
J. Rizo, C. M. Roggero, V. Esser, L. Duan, A. M. Rice, S. Ma, G. V. Raj, M. K. Rosen, Z.-P. Liu
This study investigates how poly-glutamine sequences in the androgen receptor (AR) N-terminal domain influence its activity and interactions with KDM4A, suggesting a role for phase separation in regulating AR function in prostate cancer.
bioRxiv · Oct 8, 2021Cancer Biology