Author

A. M. Silber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:metabolism & bioenergetics· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

F. S. Damasceno· 4 shared S. Marsiccobetre· 3 shared J. De Freitas Nascimento· 2 shared R. O. O. Souza· 2 shared R. W. Achjian· 2 shared A. M. Murillo· 1 shared A. R. Lima· 1 shared C. Goncalves· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

F. S. Damasceno

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Branched chain amino acids modulate the proteomic profile of Pro-induced differentiation for the infective stages of Trypanosoma cruzi

J. De Freitas Nascimento, F. S. Damasceno, S. Marsiccobetre, F. N. d. L. Vitorino, R. W. Achjian, J. P. C. da Cunha, A. M. Silber

This study investigates how branched-chain amino acids (BCAAs) affect the proteomic profile of Pro-induced differentiation in Trypanosoma cruzi, revealing metabolic changes linked to reduced infectivity.

bioRxiv · Apr 17, 2024 · PreprintBiochemistry

How much (ATP) does it cost to build a trypanosome? A theoretical study on the quantity of ATP needed to maintain and duplicate a bloodstream-form Trypanosoma brucei cell

J. De Freitas Nascimento, R. O. O. Souza, M. B. Alencar, S. Marsiccobetre, A. M. Murillo, F. S. Damasceno, R. M. B. M. Girard, L. Marchese, L. A. Luevano-Martinez, R. W. Achjian, J. R. Haanstra, P. Michels, A. M. Silber

The paper estimates the ATP required for maintaining and duplicating a bloodstream-form Trypanosoma brucei cell, finding that biomass production accounts for 62% of the energy budget.

bioRxiv · Mar 7, 2023 · PreprintBiochemistry

Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci

A. R. Lima, S. B. Poubel, J. N. Roson, L. P. de Lima, H. M. Costa-Silva, H. G. Silva, C. Goncalves, P. A. Galante, F. Holetz, M. C. Motta, A. M. Silber, M. C. Elias, J. P. da Cunha

bioRxiv · Oct 26, 2021Microbiology

Fatty acid oxidation participates of the survival to starvation, cell cycle progression and differentiation in the insect stages of Trypanosoma cruzi

R. O. O. Souza, F. S. Damasceno, S. Marsiccobetre, M. Biran, G. Murata, R. Curi, F. Bringaud, A. M. Silber

bioRxiv · Jan 8, 2021 · PreprintBiochemistry

The effect of memantine, an antagonist of the NMDA glutamate receptor, in in vitro and in vivo infections by Trypanosoma cruzi

H. F. Santos Souza, S. C. Rocha, F. S. Damasceno, L. N. Rapado, E. F. Pral, C. Marinho, A. M. Silber

This paper investigates memantine's effects on Trypanosoma cruzi infection in vitro and in vivo, finding it reduces parasitemia, cardiac load, and mortality in infected mice.

bioRxiv · Feb 11, 2019Microbiology