C. Goncalves

A miniaturised semi-dynamic in-vitro model of human digestion

This paper introduces a miniaturized digestion-chip that replicates human digestion dynamics with high accuracy, enabling efficient and low-cost assessment of bioactive materials.

Functional and evolutionary integration of a fungal gene with a bacterial operon

The paper shows that the fungal gene ENB1, acquired from a bacterial operon, enables iron uptake in W/S clade yeasts and evolved through horizontal transfer and gene loss.

Tunable PhenoCycler Imaging of the Murine Pre-Clinical Tumour Microenvironments

This study uses PhenoCycler imaging to analyze the tumor microenvironment in murine cancer models, revealing distinct TME features and cell-cell contact differences across cancer types.

Diverse signatures of convergent evolution in cacti-associated yeasts

This study identifies convergent evolution in cacti-associated yeasts using genomic and phenotypic data, finding thermotolerance and horizontal gene transfer as key adaptive traits.

Genomic and ecological factors shaping specialism and generalism across an entire subphylum

The paper analyzes genomic, metabolic, and ecological data from nearly all Saccharomycotina yeast species to show that intrinsic genetic factors, not trade-offs or extrinsic factors, drive variation in niche breadth.

Body size-dependent effects on the distribution patterns of phoretic mites of the multi-symbiont Rhynchophorus ferrugineus (Olivier, 1790) host

This study examines how body size affects the distribution of phoretic mites on red palm weevils across different regions and body parts, finding that larger mites dominate and smaller ones coexist with them.

Phylogenomics reveals extensive misidentification of fungal strains from the genus Aspergillus

The paper uses genome-scale phylogenomics to analyze 711 Aspergillus genomes, revealing taxonomic issues and strain misidentifications.

Disrupting peroxisomes alters lipid metabolism in melanoma and uncovers a novel therapeutic vulnerability in combination with MAPK-targeted therapies

This paper identifies a metabolic vulnerability in melanoma cells by disrupting peroxisomes and shows that combining this with MAPK-targeted therapies enhances anti-tumor effects.

Experimental effects of within-brood genetic variation on parasite resistance in a wild bird host

This study examines how within-brood genetic variation and nestling sex affect parasite resistance in eastern bluebirds, finding that female-biased nests have lower parasite loads.

Macroevolutionary diversity of traits and genomes in the model yeast genus Saccharomyces

The paper studies genetic and phenotypic diversity across 1,800 Saccharomyces strains, revealing insights into macroevolutionary processes and gene flow effects on traits.

Bagaza virus in wild birds, Portugal, 2021

The paper reports the first detection of Bagaza virus in wild birds in Portugal in 2021, showing high similarity to previously reported strains.

Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci

Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish

This study identifies two independent components of sociality in zebrafish, social tendency and social recognition, and finds that only social tendency is associated with genetic polymorphisms in candidate 'social' genes.

The pleiotropic effects of the MNK1/2-eIF4E axis support immune suppression and metastasis in a model of postpartum breast cancer.

This study shows that the MNK1/2-eIF4E axis promotes immune suppression and metastasis in postpartum breast cancer by affecting both tumor and non-tumor cells.

The MNK1/2-eIF4E axis contributes to phenotype switching, melanoma progression, and resistance to immunotherapy.

This study identifies the MNK1/2-eIF4E axis as a driver of melanoma phenotype switching, progression, and immunotherapy resistance, with potential therapeutic targeting.

Detection of hypermucoviscous Klebsiella pneumoniae sequence type 86 capsular type K2 in South America as an unexpected cause of a fatal outbreak in captivity marmosets

The paper identifies hypermucoviscous K. pneumoniae ST86 K2 as the cause of a fatal marmoset outbreak in Brazil, highlighting its zoonotic potential and public health implications.

What is known about modified insects for disease prevention?: a systematic review

This review evaluates the efficacy and effects of modified insects for disease prevention, finding promising results but highlighting the need for field-based evidence and caution regarding ecological and long-term impacts.