Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of heterogeneity on genomic signature scoring
Sandy Figiel, W. Yin, Dimitrios Doultsinos, A.M. Erickson, Ninu Poulose, Roshan Ajeet Singh, A. Magnussen, Thineskrishna Anbarasan, Renuka Teague, Mengxiao He, Joakim Lundeberg, Massimo F. Loda, Clare Verrill, Richard Colling, Pelvender S. Gill, , Alastair D. Lamb
The paper uses spatial transcriptomic data to show that bulk genomic signature scoring in prostate cancer biopsies is confounded by tumour heterogeneity, leading to inaccurate risk assessments.
European Urology · Feb 1, 2023Peer-reviewedGenomics