Author

A. Matthews

Primary ORCID profile (0000-0002-8482-0764 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

A. MatthewsiD1 paper · University of Cambridge

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Bakayoko· 1 shared A. D'Alessandro· 1 shared A. Salimov· 1 shared B. Keith· 1 shared B. Manning· 1 shared B. Raymond· 1 shared C. Anderson· 1 shared C. Lai· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

A. Bakayoko

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2 papers

Recent·Most cited

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

S. J. Skuli, A. Bakayoko, M. Kruidenier, B. Manning, P. Pammer, A. Salimov, O. Riley, G. Brake-Silla, M. Bowman, L. N. Martinez-Gutierrez, R. Buono, M. Paul, E. Saland, S. Wong, J. Xu, , M. Carroll

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

bioRxiv · Jun 7, 2024 · PreprintCancer Biology

Laboratory sprayer for testing of microbial biocontrol agents: design and calibration

Z. Erdos, P. Halswell, A. Matthews, B. Raymond

This paper designs and calibrates a low-cost laboratory sprayer for testing microbial biocontrol agents, showing reproducible bioassay results with spore deposition.

bioRxiv · Apr 22, 2020 · PreprintMicrobiology