S. Wong

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

Interplay Between FoxM1 and Dab2 Promotes Endothelial Cell Responses in Diabetic Wound Healing

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

Epsins oversee smooth muscle cell reprogramming by influencing master regulators KLF4 and OCT4.

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains

This study investigates the kinetic behavior of antibody light chain variable domain aggregation, finding non-linear concentration dependence and multiple aggregation pathways.

Cellular traits regulate fluorescence-based bio-optical phenotypes of coral photosymbionts living in-hospite

The paper examines how cellular traits influence fluorescence-based phenotypes of coral symbionts, identifying distinct phenotypic variants and linking them to photophysiological and cellular characteristics.

Human airway ex vivo models: new tools to study the airway epithelial cell response to SARS-CoV-2 infection

The paper uses ALI and iALI models to study SARS-CoV-2 infection effects on airway epithelial cells, finding increased interferon and inflammatory gene expression and epithelial damage.

A phenomic modeling approach for using chlorophyll-a fluorescence-based measurements on coral photosymbionts: a step towards bio-optical bleaching prediction

The paper develops a phenomic modeling approach using chlorophyll-a fluorescence measurements to predict coral bleaching susceptibility based on symbiont type and thermal response.

Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-beta Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis

This study identifies epsins as promoters of endothelial-to-mesenchymal transition in atherosclerosis and shows that a therapeutic peptide targeting epsin-FGFR1 interaction reduces EndoMT and atherosclerosis progression.

An amyloidosis-associated polymorphism does not alter LECT2 stability in vitro

This study investigates whether a valine-to-isoleucine polymorphism in LECT2 affects protein stability and aggregation, finding no consistent difference between variants.

Next-generation intranasal Covid-19 vaccine: a polymersome-based protein subunit formulation that provides robust protection against multiple variants of concern and early reduction in viral load of the upper airway in the golden Syrian hamster model

This paper develops an intranasal polymersome-based vaccine that provides robust protection against multiple SARS-CoV-2 variants and reduces viral load in hamsters.

Development of an Ultra Low-Cost SSVEP-based BCI Device for Real-Time On-Device Decoding

This paper develops a low-cost EEG-based BCI device using SSVEP decoding with CCA variants, achieving 95.56% accuracy and 102 bits/min ITR on an ESP32 microcontroller.

Shared and distinct genetic features in human and canine B-cell lymphomas

This study compares genetic mutations in canine and human B-cell lymphomas, identifying shared and distinct features that may affect their biology and therapeutic development.

Dynamic phase separation of the androgen receptor and its coactivators to regulate gene expression.

This study shows that androgen receptor (AR) and its co-activator MED1 form dynamic, AR-rich condensates at superenhancers in prostate cancer, which are crucial for oncogenic gene expression.

The metabolic pace of life histories across fishes

This study investigates the relationship between metabolic rate and life history traits in fishes, finding that growth performance, not maximum body mass or generation length, explains variation in resting metabolic rate.

Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients

This study examines genomic heterogeneity in canine splenic hemangiosarcoma, identifying driver mutations and intratumoral diversity across multiple regions.

Escape from nonsense mediated decay associates with anti-tumor immunogenicity

This study identifies NMD-escape fs-indels as a biomarker associated with improved response to immunotherapy in melanoma patients.

Trajectories from Snapshots: Integrated proteomic and metabolic single-cell assays reveal multiple independent adaptive responses to drug tolerance in a BRAF-mutant melanoma cell line

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

The right microbial stimulus can direct innate immune effector cells to specific organ sites to clear pathology

This paper demonstrates that microbial-based stimuli can direct innate immune effector cells to specific organs to clear pathology, independent of the disease type.

Identification of frequent activating HER2 mutations in primary canine pulmonary adenocarcinoma

This study identifies HER2 mutations in canine pulmonary adenocarcinomas, finding V659E mutations in 38% of cases and their association with drug sensitivity.

Extreme niche partitioning promotes a remarkably high diversity of soil microbiomes across eastern Antarctica.

This study analyzes soil microbiomes in eastern Antarctica to understand community structure and diversity, finding that bacterial communities show strong niche partitioning and higher diversity compared to eukaryotic and archaeal communities.

Signatures of the evolution of parthenogenesis and cryptobiosis in panagrolaimid nematodes

This study compares genomes and transcriptomes of parthenogenetic and cryptobiotic nematodes to identify genomic features linked to these traits.

Repurposing Tofacitinib As An Anti-Myeloma Therapeutic To Reverse Growth-Promoting Effects Of The Bone Marrow Microenvironment

This paper validates tofacitinib as an effective anti-myeloma therapy by reversing bone marrow microenvironment-driven growth signals in vitro and in vivo.