Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel
P. R. Strege, L. M. Cowan, C. Alcaino, A. Mazzone, C. A. Ahern, L. S. Milescu, G. Farrugia, A. Beyder
This study investigates the mechanosensitivity of NaChBac, a prokaryotic sodium channel, showing that force-induced pore opening, not voltage sensor activation, drives its response to mechanical stress.
bioRxiv · May 10, 2022Physiology