Author

C. A. Ahern

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:electrophysiology· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:differential expression· 1 Organism:E. coli· 1

Frequent Co-Authors

J. D. Galpin· 3 shared A. Accardi· 2 shared C. J. Clark· 2 shared E. Fortea· 2 shared E. Tajkhorshid· 2 shared L. Leisle· 2 shared A. Beyder· 1 shared A. Mazzone· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

J. D. Galpin

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Author profile →

6 papers

Recent·Most cited

Beta-subunit-eliminated eHAP expression (BeHAPe) cells reveal new properties of the cardiac voltage-gated sodium channel

A. Y. Minard, C. J. Clark, C. A. Ahern, R. C. Piper

The paper develops a cell line lacking endogenous NaV β-subunits to better study their effects on NaV1.5, revealing unique gating properties and hybrid behavior when multiple β-subunits are combined.

bioRxiv · Jul 8, 2023 · PreprintBiophysics

Backbone amides are key determinants of Cl- selectivity in CLC ion channels

L. Leisle, K. Lam, S. Dehghanighahnaviyeh, E. Fortea, J. D. Galpin, C. A. Ahern, E. Tajkhorshid, A. Accardi

The paper shows that backbone amides in CLC channels are critical for Cl- selectivity, as replacing them with ester groups reduces ion discrimination.

bioRxiv · Jul 1, 2022 · PreprintBiophysics

Mechanosensitive pore opening of a prokaryotic voltage-gated sodium channel

P. R. Strege, L. M. Cowan, C. Alcaino, A. Mazzone, C. A. Ahern, L. S. Milescu, G. Farrugia, A. Beyder

This study investigates the mechanosensitivity of NaChBac, a prokaryotic sodium channel, showing that force-induced pore opening, not voltage sensor activation, drives its response to mechanical stress.

bioRxiv · May 10, 2022Physiology

Tuning aromatic contributions by site-specific encoding of fluorinated phenylalanine residues in bacterial and mammalian cells

G. D. Galles, D. T. Infield, C. J. Clark, M. L. Hemshorn, S. Manikandan, F. S. Fazan, A. Rasouli, E. Tajkhorshid, J. D. Galpin, R. B. Cooley, R. A. Mehl, C. A. Ahern

This paper introduces new pyrrolysine-based aminoacyl-tRNA synthetase/tRNA pairs to site-specifically encode fluorinated phenylalanine residues in bacterial and mammalian cells, enabling experimental assessment of aromatic-pi interactions.

bioRxiv · Apr 12, 2022 · PreprintBiochemistry

Divergent Cl-and H + pathways underlie transport coupling and gating in CLC exchangers and channels

A. Accardi, L. Leisle, Y. Xu, E. Fortea, J. D. Galpin, M. Vien, C. A. Ahern, S. Berneche

This study identifies an aromatic pathway in CLC proteins that enables H+ transport and gating, revealing distinct and conserved routes for Cl- and H+ movement.

bioRxiv · Sep 5, 2019Biochemistry

Conformational Dynamics In TRPV1 Channels Reported By An Encoded Coumarin Amino Acid

X. Steinberg, M. A. Kasimova, D. Cabezas-Bratesco, J. Galpin, E. Ladron de Guevara, F. Villa, V. Carnevale, L. D. Islas, C. A. Ahern, S. E. Brauchi

This study uses a genetically encoded fluorescent amino acid to monitor conformational changes in TRPV1 channels, showing that Y671 fluorescence correlates with channel activation by capsaicin.

bioRxiv · May 14, 2017Biophysics