Rational design of chemically responsive cytokines for cancer immunotherapy
Lucia Bonati, Stephen Buckley, Leo Scheller, A. Minafra, Sandrine Georgeon, Tom Enbar, Sailan Shui, Li Tang, Bruno E. Correia
This paper designs switchable cytokines that are activated by Venetoclax, showing tumor control comparable to native cytokines and enhancing therapeutic safety.
bioRxiv · Sep 18, 2025 · PreprintBioengineering