Leo Scheller

This paper develops DROP-CARs, drug-regulated CAR-T cells that control cell-cell interactions using small-molecule switches, showing in vitro and in vivo functionality.

This paper designs switchable cytokines that are activated by Venetoclax, showing tumor control comparable to native cytokines and enhancing therapeutic safety.

This paper designs phosphorylation-induced protein switches that control transcription in cells, demonstrating their functionality in synthetic signaling.

The paper develops caffeine-inducible systems for controlling gene expression in human cells using humanized protein components and demonstrates their use in inducible gene expression in T-cells.

This paper designs proteins that target neosurfaces from protein-ligand complexes using a deep learning approach, validated experimentally against three drug-bound protein complexes.

This paper designs protein-based bandpass filters that respond to chemical concentrations, showing OFF-ON-OFF regulation and controlling cellular signaling pathways.