Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent minimal MET receptor agonist.
G. de Nola, B. Leclerc, A. Mougel, S. Dezitter-Taront, C. Simonneau, F. Forneris, E. Adriaenssens, H. Drobecq, O. Melnyk, E. Gherardi, H. de Jonge, J. Vicogne
This study designs and characterizes K1K1, a minimal MET receptor agonist made from two kringle 1 domains of HGF/SF, showing stability and biological activity comparable to native HGF/SF in vitro and in a mouse liver disease model.
bioRxiv · Jul 20, 2020Bioengineering