E. Adriaenssens

Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

This study identifies NAP1 and SINTBAD as regulators of mitophagy, inhibiting OPTN-driven initiation while promoting NDP52-driven progression.

Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin

This study identifies an unconventional mechanism by which OPTN initiates mitophagy through TBK1 and the class III phosphatidylinositol 3-kinase complex I, distinct from the FIP200-ULK1/2 pathway.

Dimerization of kringle 1 domain from hepatocyte growth factor/scatter factor provides a potent minimal MET receptor agonist.

This study designs and characterizes K1K1, a minimal MET receptor agonist made from two kringle 1 domains of HGF/SF, showing stability and biological activity comparable to native HGF/SF in vitro and in a mouse liver disease model.

BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes

This study shows that BAG3 Pro209 mutants cause aggresome formation and disrupt chaperone-assisted selective autophagy, leading to protein homeostasis loss regardless of clinical phenotype.

Dysregulated interactions triggered by a neuropathy-causing mutation in the IPV motif of HSP27

This study investigates how the P182L mutation in HSP27's IxI/V motif disrupts protein interactions, leading to aggregation and disease.

Viromic analysis of wastewater input to a river catchment reveals a diverse assemblage of RNA viruses

The paper uses viromics to detect RNA viruses in wastewater and river systems, identifying novel norovirus genomes and suggesting zoonotic transmission risks.