De Novo Design of Immunoglobulin-like Domains
T. M. Chidyausiku, S. R. Mendes, J. C. Klima, U. Eckhard, S. Houliston, M. Nadal, J. Roel-Touris, T. Guevara, H. K. Haddox, A. Moyer, C. H. Arrowsmith, F. X. Gomis-Rüth, D. Baker, E. Marcos
This paper introduces design rules for immunoglobulin-like domains and demonstrates the de novo creation of stable, functional scaffolds with improved biophysical properties.
bioRxiv · Dec 20, 2021 · PreprintBiochemistry