Author

J. C. Klima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Moyer· 1 shared A. R. Tobin· 1 shared C. H. Arrowsmith· 1 shared D. Baker· 1 shared D. V. Urusova· 1 shared E. Marcos· 1 shared E.-M. M. Strauch· 1 shared F. X. Gomis-Rüth· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. Moyer

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Author profile →

2 papers

Recent·Most cited

Inhibition of a critical malaria host-pathogen interaction by a computationally designed inhibitor targeting Plasmodium vivax DBP

A. R. Tobin, R. Crow, D. V. Urusova, J. C. Klima, N. H. Tolia, E.-M. M. Strauch

The paper designs a small, stable protein inhibitor that blocks the Plasmodium vivax DBP-DARC interaction, offering a potential therapeutic for malaria.

bioRxiv · Feb 5, 2022 · PreprintBioengineering

De Novo Design of Immunoglobulin-like Domains

T. M. Chidyausiku, S. R. Mendes, J. C. Klima, U. Eckhard, S. Houliston, M. Nadal, J. Roel-Touris, T. Guevara, H. K. Haddox, A. Moyer, C. H. Arrowsmith, F. X. Gomis-Rüth, D. Baker, E. Marcos

This paper introduces design rules for immunoglobulin-like domains and demonstrates the de novo creation of stable, functional scaffolds with improved biophysical properties.

bioRxiv · Dec 20, 2021 · PreprintBiochemistry