Author

S. Houliston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:protein structure· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. H. Arrowsmith· 4 shared M. Schapira· 3 shared A. Dong· 2 shared R. Ferreira De Freitas· 2 shared V. Santhakumar· 2 shared A. Ahlner· 1 shared A. Allali-Hassani· 1 shared A. Bolotokova· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

C. H. Arrowsmith

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A resource to enable chemical biology and drug discovery of WDR Proteins

C. H. Arrowsmith, S. Ackloo, F. Li, M. Szewczyk, A. Seitova, P. Loppnau, H. Zeng, S. Ahmad, S. Beldar, A. Bolotokova, I. Chau, S. Dehghani-Tafti, A. Dong, P. Ghiabi, E. Gibson, , Arnautova

The paper develops a resource for discovering ligands for WDR proteins using experimental and computational methods, leading to the identification of drug-like ligands for 9 out of 20 targets.

bioRxiv · Mar 3, 2024Biochemistry

De Novo Design of Immunoglobulin-like Domains

T. M. Chidyausiku, S. R. Mendes, J. C. Klima, U. Eckhard, S. Houliston, M. Nadal, J. Roel-Touris, T. Guevara, H. K. Haddox, A. Moyer, C. H. Arrowsmith, F. X. Gomis-Rüth, D. Baker, E. Marcos

This paper introduces design rules for immunoglobulin-like domains and demonstrates the de novo creation of stable, functional scaffolds with improved biophysical properties.

bioRxiv · Dec 20, 2021 · PreprintBiochemistry

The PNUTS-PAD domain recruits MYC to the PNUTS:PP1 phosphatase complex via the oncogenic MYC-MB0 region

Y. Wei, A. Ahlner, C. Redel, A. Lemak, I. Johansson-Akhe, S. Houliston, T. M. G. Kenney, A. Tamachi, V. Morad, S. Duan, D. W. Andrews, B. Wallner, M. Sunnerhagen, C. H. Arrowsmith, L. Z. Penn

This paper identifies the MB0 region of MYC as a direct binder to the PNUTS amino-terminal domain (PAD), revealing a molecular mechanism for MYC regulation by the PNUTS:PP1 phosphatase complex.

bioRxiv · Dec 2, 2021Cancer Biology

Identification and Characterization of the First Fragment Hits for SETDB1 Tudor Domain

P. Mader, R. Mendoza-Sanchez, A. Iqbal, A. Dong, E. Dobrovetsky, V. Corless, S. Liew, S. Houliston, R. Ferreira De Freitas, D. Smil, C. Dela Sena, S. Kennedy, D. Diaz, H. Wu, L. Dombrovski, , C. Arrowsmith

The paper identifies small molecule fragments that bind to the tudor domain of SETDB1 and describes their binding modes and biophysical properties.

Bioorganic & Medicinal Chemistry · Sep 1, 2019Peer-reviewedPharmacology & Toxicology

Discovery of small molecule antagonists of the USP5 zinc finger ubiquitin-binding domain

M. K. Mann, I. Franzoni, R. Ferreira de Freitas, W. Tempel, S. Houliston, C. H. Arrowsmith, R. J. Harding, M. Schapira

The paper identifies small molecule antagonists targeting the USP5 ZnF-UBD, providing a framework for developing chemical probes to study its role in ubiquitin signaling.

bioRxiv · Jun 22, 2019Pharmacology & Toxicology