Recurrent Emergence of an Antiviral Defense through Repeated Retrotransposition and Truncation of CHMP3
L. Rheinemann, D. M. Downhour, K. A. Davenport, A. N. McKeown, W. I. Sundquist, N. C. Elde
This study identifies retroCHMP3 as an antiviral defense mechanism that inhibits HIV-1 budding by disrupting the ESCRT pathway, showing distinct evolutionary paths in New World monkeys and mice.
bioRxiv · Apr 27, 2021 · PreprintEvolutionary Biology