Author

D. M. Downhour

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:non-human primate· 2 Research Focus:development & morphogenesis· 1 Organism:virus· 1

Frequent Co-Authors

N. C. Elde· 3 shared K. A. Davenport· 2 shared L. Rheinemann· 2 shared W. I. Sundquist· 2 shared A. N. McKeown· 1 shared A. P. Schmitt· 1 shared C. R. Necessary· 1 shared G. Mercenne· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersEvolutionary Biology

N. C. Elde

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Author profile →

3 papers

Recent·Most cited

Hidden evolutionary constraints dictate the retention of coronavirus accessory genes

S. A. Goldstein, T. M. Feeley, K. M. Babler, Z. A. Hilbert, D. M. Downhour, N. Moshiri, N. C. Elde

The paper investigates how evolutionary constraints affect the retention of coronavirus accessory genes through experimental evolution and comparative analysis of SARS-CoV-2.

bioRxiv · Oct 12, 2023Evolutionary Biology

Recurrent Emergence of an Antiviral Defense through Repeated Retrotransposition and Truncation of CHMP3

L. Rheinemann, D. M. Downhour, K. A. Davenport, A. N. McKeown, W. I. Sundquist, N. C. Elde

This study identifies retroCHMP3 as an antiviral defense mechanism that inhibits HIV-1 budding by disrupting the ESCRT pathway, showing distinct evolutionary paths in New World monkeys and mice.

bioRxiv · Apr 27, 2021 · PreprintEvolutionary Biology

RetroCHMP3 Blocks Budding of Enveloped Viruses Without Blocking Cytokinesis

L. Rheinemann, D. M. Downhour, K. Bredbenner, G. Mercenne, K. A. Davenport, P. T. Schmitt, C. R. Necessary, J. McCullough, A. P. Schmitt, S. M. Simon, W. I. Sundquist, N. C. Elde

The paper identifies duplicated and truncated CHMP3 variants in New World monkeys and mice that inhibit enveloped virus budding without affecting essential cellular ESCRT functions.

bioRxiv · Aug 30, 2020Immunology