Author

A. N. O'Toole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:variant calling· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

A. Rambaut· 3 shared M. Chand· 2 shared N. Groves· 2 shared N. Loman· 2 shared R. Myers· 2 shared A. Carabelli· 1 shared A. de Bernardi Schneider· 1 shared A. Price· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersEvolutionary Biology

A. Rambaut

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3 papers

Recent·Most cited

Automated Agnostic Designation of Pathogen Lineages

J. McBroome, A. de Bernardi Schneider, C. Roemer, M. T. Wolfinger, A. S. Hinrichs, A. N. O'Toole, C. Ruis, Y. Turakhia, A. Rambaut, R. Corbett-Detig

The paper introduces an automated method for pathogen lineage designation using phylogenetic trees, offering a consistent alternative to manual curation.

bioRxiv · Feb 3, 2023 · PreprintEvolutionary Biology

Putative APOBEC3 deaminase editing in MPXV as evidence for sustained human transmission since at least 2016.

A. N. O'Toole, R. Neher, N. Ndodo, V. Borges, B. Gannon, J. P. Gomes, N. Groves, D. J. King, D. Maloney, P. Lemey, K. Lewandowski, N. Loman, R. Myers, M. A. Suchard, M. Worobey, , A. Rambaut

The paper analyzes MPXV genomes to show evidence of APOBEC3 deaminase editing, suggesting sustained human transmission since 2016.

bioRxiv · Jan 23, 2023 · PreprintEvolutionary Biology

The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK

V. Hill, L. du Plessis, T. P. A. Peacock, D. Aggarwal, A. Carabelli, R. Colquhoun, N. Ellaby, E. Gallagher, N. Groves, B. Jackson, J. McCrone, A. N. O'Toole, A. Price, T. Sanderson, E. Scher, , A. Rambaut

This study investigates the origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 (Alpha) in the UK, finding that a chronically-infected immunocompetent individual likely drove its rapid mutation and spread.

bioRxiv · Mar 8, 2022Evolutionary Biology