T. Sanderson

Emergence of new subgenomic mRNAs in SARS-CoV-2

This study identifies new subgenomic mRNAs in SARS-CoV-2 arising from mutations that create novel transcription regulatory sequences, leading to the expression of functional proteins like N.iORF3.

Barcoding genetically distinct Plasmodium falciparum strains for comparative assessment of fitness and antimalarial drug resistance

This paper introduces a method to assess fitness and drug resistance in Plasmodium falciparum strains using CRISPR/Cas9 and barcode sequencing, demonstrating its ability to detect artemisinin resistance in mixed parasite populations.

The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK

This study investigates the origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 (Alpha) in the UK, finding that a chronically-infected immunocompetent individual likely drove its rapid mutation and spread.

Using Plasmodium knowlesi as a model for screening Plasmodium vivax blood-stage malaria vaccine targets reveals new candidates

This paper uses Plasmodium knowlesi as a model to screen Plasmodium vivax blood-stage vaccine targets, identifying new candidates by testing antibody inhibition of parasite invasion.

89Zr-oxine labelling and PET imaging shows lung delivery of a cell/gene cancer therapy

The paper demonstrates that 89Zr-oxine PET imaging can track MSCTRAIL cell therapy biodistribution in a lung cancer mouse model, showing lung delivery and viability.

Quantitation of vector uptake reveals non-Poissonian transfection dynamics in Plasmodium falciparum

This study quantifies vector uptake in Plasmodium falciparum and finds non-Poissonian transfection dynamics, with parasites taking up multiple vectors early and unevenly.