Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics
T. J. Walker, E. Reyes-Alvarez, B. D. Hyndman, M. G. Sugiyama, L. C. B. Oliveira, A. N. Rekab, M. J. F. Crupi, R. Cabral-Dias, Q. Guo, P. L. M. Dahia, D. S. Richardson, C. N. Antonescu, L. M. Mulligan
This study shows that TMEM127 loss leads to RET receptor accumulation on the cell surface, promoting constitutive signaling and cell proliferation in PCC.
bioRxiv · Jun 28, 2023 · PreprintCancer Biology