C. N. Antonescu

Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics

This study shows that TMEM127 loss leads to RET receptor accumulation on the cell surface, promoting constitutive signaling and cell proliferation in PCC.

Quantitative modeling of EGF receptor ligand discrimination via internalization proofreading

This study develops quantitative models to show how spatial and kinetic proofreading mechanisms enhance EGFR internalization based on ligand type.

The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signalling

This study shows that LCLAT1 is required for EGF-mediated PtdIns(3,4,5)P3 generation and Akt signaling in cancer and retinal cells.

Fatty Acid Synthase inhibitor TVB-3166 prevents S-acylation of the Spike protein of human coronaviruses.

This study shows that TVB-3166 inhibits S-acylation of coronavirus Spike proteins, reducing viral spread and improving survival in mice.

O-GlcNAc transferase modulates formation of clathrin-coated pits

This study investigates how O-GlcNAc modification regulates clathrin-coated pit formation and clathrin-mediated endocytosis.

Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence

This paper demonstrates that silver nanoparticles enhance lysosome fluorescence, enabling live-cell imaging with reduced phototoxicity and preserved dynamics.

HER2 expression defines unique requirements for flotillin and c-Src for EGFR signaling

The paper shows HER2 expression uniquely requires flotillin and c-Src for EGFR signaling and Akt activation in membrane rafts.

Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling

This study shows that EGFR confinement in tetraspanin nanodomains regulates ligand binding and signaling by preferentially facilitating ligand binding in these domains.

AMP-activated protein kinase (AMPK) is required for recovery from metabolic stress induced by ultrasound microbubble treatment

This study investigates how AMPK mediates cellular recovery from metabolic stress caused by ultrasound microbubble treatment in breast cancer cells.

Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease

mTORC1 controls glycogen synthase kinase 3β nuclear localization and function

The paper shows mTORC1 inhibits GSK3β nuclear localization and function, linking metabolic signals to transcriptional control of biomass production.