Q. Guo

Identification of Candidate Diagnostic gene CDC25C for Trametinib-induced Cardiotoxicity by Integrating Bioinformatics and Machine Learning

In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood

This study identifies PEDF as a systemic factor in young blood that rejuvenates cells and tissues, using an in vitro heterochronic parabiosis system.

The Molecular Architecture of the Nuclear Basket

This study uses structural biology to reveal the architecture of the nuclear basket in yeast and mammals, showing how Mlp/Tpr proteins form its structural components.

CPT1A Mediates Radiation Sensitivity in Colorectal Cancer

This study identifies CPT1A as a mediator of radiation sensitivity in colorectal cancer, showing its role in ROS scavenging and DNA damage response through the FOXM1-SOD1/SOD2/CAT axis.

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

This study investigates how Vps5 and Vps17 SNX-BAR proteins assemble with Retromer, revealing a PL motif in Vps5 that binds Vps29 and is essential for membrane tubule association and cargo recycling.

SARS-CoV-2 serosurvey of healthy, privately owned cats presenting to a New York City animal hospital in the early phase of the COVID-19 pandemic (2020-2021)

This study reports a serosurvey of cats in New York City during the early pandemic, finding 16% seropositive for SARS-CoV-2 with higher prevalence in fall 2020 and evidence of human-cat transmission.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

Unbiased Complete Estimation of Chloroplast Number in Plant Cells Using Deep Learning Methods

This paper introduces a deep learning method for accurate 3D chloroplast counting in plant cells, achieving over 95% accuracy compared to manual methods.

Abundant microorganisms in soil are mainly controlled by stochastic processes, while bacteria and fungi differ in rare taxa

The paper investigates how vegetation types affect bacterial and fungal community assembly in soil, finding that abundant taxa are mainly controlled by stochastic processes while rare taxa differ in their drivers.

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex

This study defines how FAM21 couples SNX27-Retromer to the WASH complex through motif-based interactions essential for endosomal recycling.

Loss of Tumour Suppressor TMEM127 Drives RET-mediated Transformation Through Disrupted Membrane Dynamics

This study shows that TMEM127 loss leads to RET receptor accumulation on the cell surface, promoting constitutive signaling and cell proliferation in PCC.

Loss of IRF5 increases ribosome biogenesis leading to alterations in mammary gland architecture and metastasis

This study shows that loss of IRF5 predicts metastasis and survival in breast cancer and reveals its role in regulating ribosome biogenesis and tumor progression.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

GLI1 facilitates rheumatoid arthritis by collaborative regulation of DNA methyltransferases

This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.

Bioinformatic analysis of the spike protein cleavage sites of coronaviruses in the mammalian order Eulipotyphla

The paper analyzes coronavirus spike protein cleavage sites in Eulipotyphla mammals, finding potential spillover risks in certain shrew coronaviruses.

Analysis and Exploration of the Implementation System of Mixed Ownership of Scientific and Technological Achievements in Colleges and Universities

The paper identifies key challenges in implementing mixed ownership systems for scientific and technological achievements in colleges and universities and proposes improvements to address these issues.

Structural insights into AT-rich DNA recognition by SALL family proteins

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.

Orchestration of alternative splicing regulates bone marrow mesenchymal stem cells fate during aging

This study identifies YBX1 deficiency causes mis-splicing in BMSCs, leading to senescence and bone loss, and shows Sciadopitysin can reverse this process.

The radio-protective effects of (-)-Epigallocatechin-3-gallate (EGCG): regulating macrophage function in radiation-induced intestinal injury.

This study shows EGCG protects against radiation-induced intestinal injury by preserving macrophages and gut microbiota, reducing inflammation and improving survival in mice.

Sugar transporter Slc37a2 regulates bone metabolism via a dynamic tubular lysosomal network in osteoclasts

This study identifies Slc37a2 as a sugar transporter in osteoclast secretory lysosomes, showing its role in bone metabolism through dynamic tubular networks and its impact on bone mass.

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds

This study shows that the AAA+ chaperone VCP disaggregates Tau fibrils and generates seeding-active Tau as a byproduct, suggesting a role in aggregate removal and spreading in tauopathies.

Collateral cleavage of 28s rRNA by RfxCas13d causes death of mice

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

Multiplexed imaging mass cytometry reveals distincttumor-immune microenvironments linked to immunotherapyresponses in melanoma

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

The special and general mechanism of cyanobacterial harmful algal blooms

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

SunCatcher: Clonal Barcoding with qPCR-Based Detection Enables Functional Analysis of Live Cells and Generation of Custom Combinations of Cells for Research and Discovery

Predicting hosts based on early SARS-CoV-2 samples and analyzing later world-wide pandemic in 2020

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

Mechanistic basis for SNX27-Retromer coupling to ESCPE-1 in promoting endosomal cargo recycling.

This study identifies the molecular mechanism by which SNX27-Retromer interacts with ESCPE-1 to facilitate endosomal cargo recycling, revealing a conserved surface interaction and evolutionary pathway.

In situ architecture of neuronal alpha-Synuclein inclusions

This study uses cryo-ET to show that neuronal alpha-Synuclein inclusions contain fibrils intermixed with cellular membranes and are nucleated by oligomers.

Rapid characterization of spike variants via mammalian cell surface display

This study characterizes SARS-CoV-2 spike variants by assessing their expression, ACE2 binding, and neutralizing antibody recognition across multiple variants.

An amiRNA screen uncovers redundant CBF & ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses