Interaction Between Phosphoinositide 3-Kinase and the VDAC2 Channel Tethers Endosomes to Mitochondria and Promotes Endosome Maturation
A. O. Satoh, Y. Fujioka, S. Kashiwagi, A. Yoshida, M. Fujioka, H. Sasajima, A. Nanbo, M. Amano, Y. Ohba
This study identifies VDAC2 as a mitochondrial protein that binds PI3K, tethers endosomes to mitochondria, and promotes endosome maturation through both structural and pore functions.
bioRxiv · Jan 18, 2021 · PreprintCell Biology