A. Yoshida

Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms

This study develops a live-attenuated SARS-CoV-2 vaccine candidate, BK2102, which induces long-term immunity and is safe in animal models.

Migratory pattern of zoonotic Toxocara cati and T. canis in experimentally infected pigs

This study investigates the migratory patterns of Toxocara cati and T. canis in pigs, finding both species equally infective and capable of causing neurological toxocarosis.

A method for the generation of pseudotyped virus particles bearing SARS coronavirus spike protein in high yields

This paper describes an improved method to produce SARS-CoV and SARS-CoV-2 Spike protein pseudotyped VSV particles for coronavirus entry studies and antiviral development.

Versatile live attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

This study develops a live attenuated SARS-CoV-2 vaccine platform using temperature-sensitive mutations that provides protection against homologous and heterologous viral challenges.

Interaction Between Phosphoinositide 3-Kinase and the VDAC2 Channel Tethers Endosomes to Mitochondria and Promotes Endosome Maturation

This study identifies VDAC2 as a mitochondrial protein that binds PI3K, tethers endosomes to mitochondria, and promotes endosome maturation through both structural and pore functions.

Localization of BCR-ABL to stress granules contributes to its oncogenic function

This study shows BCR-ABL localizes to stress granules, and this localization contributes to its oncogenic function in CML.

Folding latency of fluorescent proteins affects the mitochondrial localization of fusion protein

The paper shows that faster folding fluorescent proteins can mislocalize mitochondrial-targeted fusion proteins, and slowing their folding improves mitochondrial localization.

Characterization of the gastric motility response to human motilin and erythromycin in human motilin receptor-expressing transgenic mice

This study shows that human motilin and erythromycin stimulate gastric motility in human motilin receptor-expressing transgenic mice through Ca2+ influx, suggesting these mice are useful for testing MTLR agonists.

Morphological changes of plasma membrane and protein assembly during clathrin-mediated endocytosis

This study visualizes membrane morphology and protein dynamics during clathrin-mediated endocytosis in living cells, revealing actin's role in pit closure.