PCNA has specific functions in regulation of metabolism in haematological cells
L. M. Rost, C. Olaisen, A. Sharma, A. Nedal, V. Petrovic, H. F. N. Kvitvang, P. Bruheim, M. Otterlei
The paper shows that inhibiting PCNA's cytosolic scaffold function reduces glycolytic metabolites and nucleoside phosphate pools specifically in haematological cancer cells, suggesting a role in metabolic regulation.
bioRxiv · Apr 29, 2020 · PreprintCell Biology