M. Otterlei

Activation of the Cpx-envelope stress response system promotes tolerance to antibacterials delivered by arginine-rich peptides and aminoglycosides in Escherichia coli

The paper shows that Escherichia coli resistance to arginine-rich CPP-PNA conjugates involves the constitutively active Cpx-envelope stress response system, which reduces membrane potential and increases tolerance to aminoglycosides.

PCNA has specific functions in regulation of metabolism in haematological cells

The paper shows that inhibiting PCNA's cytosolic scaffold function reduces glycolytic metabolites and nucleoside phosphate pools specifically in haematological cancer cells, suggesting a role in metabolic regulation.