Pharmacology & ToxicologybioRxiv
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys
DOI 10.1021/acs.jmedchem.3c00750
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A. M. Gomez, R. C. Brewer, J.-S. Moon…·W. H. Robinson
The study functionally characterizes ACPAs from RA patients and shows they reduce arthritis severity in a mouse model, with effects dependent on timing of treatment.