Author

A. Nikoubashman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Assay:multiome· 1 Assay:protein sequence· 1

Frequent Co-Authors

J. Mittal· 5 shared Y. C. Kim· 4 shared D. S. Devarajan· 3 shared J. Wang· 3 shared S. Rekhi· 3 shared D. Sundaravadivelu Devarajan· 2 shared M. P. Howard· 2 shared B. Szała-Mendyk· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersBiophysics

J. Mittal

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6 papers

Recent·Most cited

Sequence-Dependent Conformational Transitions of Disordered Proteins During Condensation

J. Wang, D. Sundaravadivelu Devarajan, Y. C. Kim, A. Nikoubashman, J. Mittal

This study investigates how sequence patterns in intrinsically disordered proteins affect their conformational transitions during condensation using a polyampholyte model.

bioRxiv · Jan 11, 2024Biophysics

Conformational Properties of Polymers at Droplet Interfaces as Model Systems for Disordered Proteins

J. Wang, D. S. Devarajan, A. Nikoubashman, J. Mittal

The paper uses polymer models to study conformational properties at droplet interfaces, finding compact conformations and segmental enrichment at the interface, which mirrors behavior in natural proteins.

bioRxiv · Jul 29, 2023Biophysics

Sequence-Dependent Material Properties of Biomolecular Condensates and their Relation to Dilute Phase Conformations

D. S. Devarajan, J. Wang, B. Szała-Mendyk, S. Rekhi, A. Nikoubashman, Y. C. Kim, J. Mittal

This study computationally examines how sequence composition of charged disordered proteins affects their condensate material properties and finds similar responses to charge segregation across different sequences.

bioRxiv · May 9, 2023 · PreprintBiophysics

Role of Strong Localized vs. Weak Distributed Interactions in Disordered Protein Phase Separation

S. Rekhi, D. Sundaravadivelu Devarajan, M. P. Howard, Y. C. Kim, A. Nikoubashman, J. Mittal

This study compares phase separation in intrinsically disordered proteins using two models with different interaction strengths and distributions, finding that distributed interactions promote liquid-like condensates over a broader range of compositions.

bioRxiv · Jan 27, 2023Biophysics

Effect of Charge Distribution on the Dynamics of Polyampholytic Disordered Proteins

D. S. Devarajan, S. Rekhi, A. Nikoubashman, Y. C. Kim, M. P. Howard, J. Mittal

This study examines how charge distribution affects the dynamics of polyampholytic disordered proteins in dilute solutions, showing conformational and dynamic changes with increasing charge segregation.

bioRxiv · Jul 4, 2022Biophysics

Single-chain and condensed-state behavior of hnRNPA1 from molecular simulations

D. J. Bauer, L. S. Stelzl, A. Nikoubashman

This study uses molecular simulations to investigate how aromatic residues affect the conformation and phase behavior of hnRNPA1's low-complexity domain, revealing their role in condensation and critical temperature changes.

bioRxiv · Apr 13, 2022Biophysics