Author

A. O'Connell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

F. Douam· 2 shared M. Saeed· 2 shared A. Bandara· 1 shared A. D. Klose· 1 shared A. H. Munawar· 1 shared A. Munawar· 1 shared B. R. Huber· 1 shared D. Kenney· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersPathology

F. Douam

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Enhancing Breast Ultrasound Segmentation through Fine-tuning and Optimization Techniques: Sharp Attention UNet

D. Khaledyan, T. J. Marini, A. O'Connell, K. Parker

This paper evaluates optimization and fine-tuning techniques for UNet variants in breast ultrasound segmentation, introducing Sharp Attention UNet which achieves high performance metrics.

bioRxiv · Jul 14, 2023Bioengineering

Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

M. Carossino, P. Montanaro, A. O'Connell, D. Kenney, H. Gertje, K. Grosz, M. Ericsson, B. R. Huber, S. Subramaniam, T. A. Kirkland, J. R. Walker, K. P. Francis, A. D. Klose, N. Paragas, S. Kurnick, , N. Crossland

This study investigates SARS-CoV-2 infection in K18-hACE2 mice, showing neuroinvasion and neuronal injury are key to lethality, with viral tropism not fully dependent on hACE2 expression.

bioRxiv · Jan 13, 2021 · PreprintPathology

The Effect Of Famotidine On SARS-CoV-2 Proteases And Virus Replication

M. Loffredo, H. Lucero, D.-Y. Chen, A. O'Connell, S. Bergqvist, A. Munawar, A. Bandara, S. DeGraef, S. D. Weeks, F. Douam, M. Saeed, A. H. Munawar

This study investigates famotidine's effect on SARS-CoV-2 proteases and virus replication, finding no direct inhibition of 3CLpro, PLpro, or viral replication at high concentrations.

bioRxiv · Jul 15, 2020Pharmacology & Toxicology