Author

N. Crossland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pathology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 3 Assay:spatial transcriptomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

I. Kramnik· 2 shared L. Kobzik· 2 shared S. M. Yabaji· 2 shared A. Belkina· 1 shared A. D. Klose· 1 shared A. E. Tseng· 1 shared A. Gimelbrant· 1 shared A. Griffiths· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

I. Kramnik

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung

S. M. Yabaji, S. Lata, A. E. Tseng, P. B. Araveti, M. Lo, I. Gavrish, A. K. O'Connel, H. P. Gertje, A. Belkina, C. E. Thurman, H. Kiyokawa, D. N. Kotton, S. Tan, J. J. Endsley, W. R. Bishai, , I. Kramnik

This study identifies aberrant macrophage activation and maladaptive lung repair as key factors promoting tuberculosis progression in the lung using a novel mouse model.

bioRxiv · Oct 17, 2023 · PreprintImmunology

Extensive and Persistent Extravascular Dermal Fibrin Deposition Characterizes Systemic Sclerosis

J. L. Browning, J. Bhawan, A. Tseng, N. Crossland, A. M. Bujor, K. Akassoglou, S. Assassi, B. Skaug, J. Ho

This study identifies extensive and persistent dermal fibrin deposition in systemic sclerosis, suggesting ongoing vascular leakage and impaired fibrin clearance contribute to fibrosis.

bioRxiv · Jan 16, 2023 · PreprintPathology

Comparative infection and pathogenesis of SARS-CoV-2 Omicron and Delta variants in aged and young Syrian hamsters

N. Storm, N. Crossland, L. McKay, A. Griffiths

This study compares SARS-CoV-2 Delta and Omicron variants' infection dynamics and pathogenesis in aged and young Syrian hamsters, finding Omicron causes less severe disease with no weight loss and reduced tissue damage.

bioRxiv · Mar 2, 2022 · PreprintMicrobiology

Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

M. Carossino, P. Montanaro, A. O'Connell, D. Kenney, H. Gertje, K. Grosz, M. Ericsson, B. R. Huber, S. Subramaniam, T. A. Kirkland, J. R. Walker, K. P. Francis, A. D. Klose, N. Paragas, S. Kurnick, , N. Crossland

This study investigates SARS-CoV-2 infection in K18-hACE2 mice, showing neuroinvasion and neuronal injury are key to lethality, with viral tropism not fully dependent on hACE2 expression.

bioRxiv · Jan 13, 2021 · PreprintPathology

Maladaptive oxidative stress cascade drives type I interferon hyperactivity in TNF activated macrophages promoting necrosis in murine tuberculosis granulomas

E. Brownhill, S. M. Yabaji, V. Zhernovkov, O. S. Rukhlenko, K. Seidel, B. Bhattacharya, S. Chatterjee, H. A. Chen, N. Crossland, W. Bishai, B. N. Kholodenko, A. Gimelbrant, L. Kobzik, I. Kramnik

This study identifies a maladaptive oxidative stress cascade in TNF-activated macrophages that drives IFN-I hyperactivity and necrosis in murine tuberculosis granulomas, with potential therapeutic targets identified.

bioRxiv · Dec 14, 2020 · PreprintImmunology