This study investigates VAERD risks in vaccinated mice following SARS-CoV-2 breakthrough infections, revealing Th2/Th17-driven pulmonary immunopathology.

bioRxiv · Oct 18, 2023Immunology

Experimental infection of Mexican free-tailed bats (Tadarida brasiliensis) with SARS-CoV-2.

J. Hall, E. Hofmeister, H. Ip, S. Nashold, A. Leon, C. Malave, E. Falendysz, T. Rocke, M. Carossino, U. Balasuriya, S. Knowles

This study infects Mexican free-tailed bats with SARS-CoV-2 and finds they can become infected but do not show disease symptoms or transmit the virus.

bioRxiv · Jul 18, 2022Pathology

Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant

N. N. Gaudreault, K. Cool, J. D. Trujillo, I. Morozov, D. A. Meekins, C. D. McDowell, D. Bold, M. Carossino, V. Balaraman, D. Mitzel, T. Kwon, D. W. Madden, B. L. Artiaga, R. Pogranichniy, G. Roman-Sosa, , J. A. Richt

This study investigates sheep susceptibility to SARS-CoV-2 and finds that they show low susceptibility, with the alpha variant outcompeting the ancestral lineage.

bioRxiv · Nov 15, 2021Microbiology

Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer

K. Cool, N. N. Gaudreault, I. Morozov, J. D. Trujillo, D. A. Meekins, C. McDowell, M. Carossino, D. Bold, T. Kwon, V. Balaraman, D. W. Madden, B. Libanori Artiaga, R. M. Pogranichniy, G. Roman Sosa, J. Henningson, , J. A. Richt

This study shows adult white-tailed deer are susceptible to SARS-CoV-2 and can transmit it vertically and horizontally, with the alpha variant outcompeting the ancestral strain.

bioRxiv · Aug 15, 2021Microbiology

Experimental re-infected cats do not transmit SARS-CoV-2

N. N. Gaudreault, M. Carossino, I. Morozov, J. D. Trujillo, D. A. Meekins, D. W. Madden, K. Cool, B. Libanori Artiaga, C. McDowell, D. Bold, V. Balaraman, T. Kwon, W. Ma, J. Henningson, D. W. Wilson, , J. A. Richt

This study shows that SARS-CoV-2 can re-infect previously infected cats, but viral shedding is insufficient for transmission to naive cats.

bioRxiv · Jan 18, 2021Microbiology

Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression

M. Carossino, P. Montanaro, A. O'Connell, D. Kenney, H. Gertje, K. Grosz, M. Ericsson, B. R. Huber, S. Subramaniam, T. A. Kirkland, J. R. Walker, K. P. Francis, A. D. Klose, N. Paragas, S. Kurnick, , N. Crossland

This study investigates SARS-CoV-2 infection in K18-hACE2 mice, showing neuroinvasion and neuronal injury are key to lethality, with viral tropism not fully dependent on hACE2 expression.

bioRxiv · Jan 13, 2021 · PreprintPathology

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

J. S. Y. Ho, B. W.-Y. Mok, L. Campisi, T. Jordan, S. Yildiz, S. Parameswaran, J. A. Wayman, N. N. Gaudreault, D. A. Meekins, S. V. Indran, I. Morozov, J. D. Trujillo, Y. S. Fstkchyan, R. Rathnasinghe, Z. Zhu, , Jeya

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

bioRxiv · Dec 1, 2020 · PreprintMicrobiology

SARS-CoV-2 infection, disease and transmission in domestic cats

N. N. Gaudreault, J. D. Trujillo, M. Carossino, D. A. Meekins, I. Morozov, D. W. Madden, S. V. Indran, D. Bold, V. Balaraman, T. Kwon, B. Libanori Artiaga, K. Cool, A. Garcia-Sastre, W. Ma, W. C. Wilson, , J. A. Richt

This study investigates SARS-CoV-2 infection, disease progression, and transmission in domestic cats through experimental challenge and monitoring.

bioRxiv · Aug 4, 2020Microbiology