Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression
M. Carossino, P. Montanaro, A. O'Connell, D. Kenney, H. Gertje, K. Grosz, M. Ericsson, B. R. Huber, S. Subramaniam, T. A. Kirkland, J. R. Walker, K. P. Francis, A. D. Klose, N. Paragas, S. Kurnick, , N. Crossland
This study investigates SARS-CoV-2 infection in K18-hACE2 mice, showing neuroinvasion and neuronal injury are key to lethality, with viral tropism not fully dependent on hACE2 expression.
bioRxiv · Jan 13, 2021 · PreprintPathology