Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo
H. Kobayashi, T. Morikawa, A. Okinaga, F. Hamano, T. Hashidate-Yoshida, S. Watanuki, D. Hishikawa, H. Shindou, F. Arai, Y. Kabe, M. Suematsu, T. Shimizu, K. Takubo
This study maintains engraftable quiescent HSCs in culture for 1 month using low cytokines, hypoxia, and high fatty acids.
bioRxiv · Dec 6, 2018Cell Biology